Louisville River Cruises

River Cruises that visit North America: United States: Kentucky: Louisville

River Cruises that depart from Louisville

See all Cruises that visit Louisville

Ohio River Cruises

Click on a cruise ship itinerary that visits Louisville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

22 Night - Pittsburgh to Minneapolis
Starting in Pittsburgh, PA; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO; St. Louis (Alton), MO; Hannibal, MO; Bettendorf, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; Minneapolis (Red Wing), MN
2023 Sails: Aug 14, More...

American Queen Voyages, American Countess

8 Night - Louisville to St. Louis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2023 Sails: Aug 21, 2024: Jul 13, More...

American Queen Voyages, American Countess

8 Night - Burbon: An American Spirit Cruise from Louisville to St. Louis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2023 Sails: Aug 21, More...

American Queen Voyages, American Duchess

8 Night - Nashville to Cincinnati
Starting in Nashville, TN; with stops in Clarksville, TN; Dover, TN; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2024 Sails: Apr 22, More...

American Queen Voyages, American Duchess

8 Night - Roundtrip Cincinnati
Starting in Cincinnati, OH; with stops in Louisville, KY; Madison, IN; Brandenburg, KY; Louisville, KY; Augusta, KY; Cincinnati, OH
2024 Sails: Apr 29, More...

American Queen Voyages, American Duchess

8 Night - Louisville to Memphis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; Ashport Landing, TN; Memphis, TN
2024 Sails: May 20, More...

American Cruise Lines, American Melody

14 Night - Grand Ohio River Cruise from St. Louis, MO to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Evansville, IN; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2024 Sails: Jun 29, More...

American Cruise Lines, American Heritage

American Cruise Lines, American Melody

14 Night - Grand Ohio River Cruise from Pittsburgh, PA to St. Louis, MO
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Evansville, IN; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2024 Sails: Jul 13, More...

American Cruise Lines, American Heritage

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