Louisville River Cruise Departures

River Cruises that depart from North America: United States: Kentucky: Louisville

River Cruises that visit Louisville

See all Cruises that depart from Louisville

Ohio River Cruises

Click on a cruise ship itinerary sailing from Louisville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

8 Night - Louisville to Cincinnati
Starting in Louisville, KY; with stops in Madison, IN; Brandenburg, KY; Louisville, KY; Augusta, KY; Cincinnati, OH
2023 Sails: May 1, More...

American Queen Voyages, American Countess

8 Night - Kentucky Derby Cruise from Louisville to Cincinnati
Starting in Louisville, KY; with stops in Madison, IN; Brandenburg, KY; Louisville, KY; Augusta, KY; Cincinnati, OH
2023 Sails: May 1, More...

American Queen Voyages, American Countess

8 Night - Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2023 Sails: May 22, Jun 5, Aug 7, 2024: Jun 15, Jun 29, More...

American Queen Voyages, American Countess

8 Night - Founder's Cruise from Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2023 Sails: Jun 5, More...

American Queen Voyages, American Countess

8 Night - Louisville to Nashville
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2023 Sails: Jun 19, More...

American Queen Voyages, American Countess

8 Night - Louisville to St. Louis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2023 Sails: Aug 21, 2024: Jul 13, More...

American Queen Voyages, American Countess

8 Night - Burbon: An American Spirit Cruise from Louisville to St. Louis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2023 Sails: Aug 21, More...

American Queen Voyages, American Duchess

8 Night - Louisville to Memphis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; Ashport Landing, TN; Memphis, TN
2024 Sails: May 20, More...

Louisville River Cruise Departures