Cape Town Cruise Departures

Cruises that depart from Africa: South Africa: Cape Town

Cruises that visit Cape Town

See all River Cruises that depart from Cape Town

Click on a cruise ship itinerary sailing from Cape Town (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Cape Town), please visit: Cruise Search or try our Virtual Cruise Advisor™.

4 Night - Cape Town, Walvis Bay, Cape Town
Starting in Cape Town with stops in Walvis Bay
2023 Sails: Feb 6, Feb 13, Feb 27, Mar 6, More...

Azamara, Azamara Journey

12 Night - South Africa Intensive Voyage onboard Azamara Journey
Starting in Cape Town with stops in Port Elizabeth, East London, Maputo, Richards Bay, Durban
2023 Sails: Feb 8, More...

MSC Cruises, MSC Sinfonia

3 Night - Cape Town, Mossel Bay, Cape Town
Starting in Cape Town with stops in Mossel Bay
2023 Sails: Feb 10, Feb 17, Mar 3, More...

Azamara, Azamara Journey

12 Night - South Africa Intensive Voyage onboard Azamara Journey
Starting in Cape Town with stops in Port Elizabeth, East London, Maputo, Richards Bay, Durban
2023 Sails: Feb 20, More...

MSC Cruises, MSC Sinfonia

5 Night - Cape Town, Walvis Bay, Luderitz, Cape Town
Starting in Cape Town with stops in Walvis Bay, Luderitz
2023 Sails: Feb 20, More...

MSC Cruises, MSC Sinfonia

2 Night - Cape Town, Indian Ocean, Cape Town
Starting in Cape Town with stops in Indian Ocean
2023 Sails: Feb 25, More...

Azamara, Azamara Journey

21 Night - Western Africa Voyage onboard Azamara Journey
Starting in Cape Town with stops in Walvis Bay, Luanda, Takoradi, Abidjan, Banjul, Gran Canaria, Tenerife, Funchal, Lisbon
2023 Sails: Mar 4, More...

MSC Cruises, MSC Sinfonia

34 Night - Cape Town, Walvis Bay, Cape Town, Durban, La Possession, Port Louis, Port Louis, Port Victoria, Port Victoria, Jeddah, Safaga, Sharm El-Sheikh, Sokhna Port, Suez Canal South, Suez Canal North, Heraklion, Piraeus, Split, Venice
Starting in Cape Town with stops in Walvis Bay, Durban, La Possession, Port Louis, Port Victoria, Jeddah, Safaga, Sharm El-Sheikh, SOKHNA PORT, Suez Canal South, Suez Canal North, Heraklion, Piraeus, Split, Venice
2023 Sails: Mar 6, More...

AmaWaterways, Zambezi Queen

9 Night - Discover Africa : Cape Town to Johannesburg : 3 Nights Capetown, 4-Night Safari Cruise, 2 Nights Victoria Falls : ms Zambezi Queen
Starting in Cape Town with stops in Victoria Falls, Zambezi Queen, Johannesburg
2023 Sails: Mar 10, Mar 17, Mar 31, Apr 7, Apr 14, Apr 28, May 5, May 12, May 19, Jun 2, Jun 9, Jun 23, Jun 30, Jul 14, Jul 21, Aug 4, Aug 11, Aug 18, Sep 1, Sep 8, Sep 15, Sep 22, Oct 6, Oct 13, More...

AmaWaterways, Zambezi Queen

12 Night - Rivers & Rails of Africa : Cape Town to Johannesburg : 3 Nights Cape Town, 4-Night Safari Cruise, 2 Nights Victoria Falls, 3 Nights Rovos Rail : ms Zambezi Queen
Starting in Cape Town with stops in Zambezi Queen, Victoria Falls, Rovos Rail, Pretoria
2023 Sails: Mar 10, Mar 17, Mar 31, Sep 1, Sep 8, Sep 15, Sep 22, Oct 6, Oct 13, Oct 20, More...

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Cape Town Cruise Departures