St Louis Cruise Departures
Cruises that depart from North America: United States: Missouri: St Louis
Cruises that visit St Louis
See all River Cruises that depart from St Louis
Cruises that depart from North America: United States: Missouri: St Louis
Cruises that visit St Louis
See all River Cruises that depart from St Louis
Click on a cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.
8 Night - St. Louis to Minneapolis
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 3, Jul 17, Aug 28, 2024: Aug 17, Sep 28, More...
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 3, Jul 17, Aug 28, 2024: Aug 17, Sep 28, More...
7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, 2024: Sep 28, More...
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, 2024: Sep 28, More...
10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2023 Sails: Jul 11, Jul 31, Aug 20, Sep 9, More...
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2023 Sails: Jul 11, Jul 31, Aug 20, Sep 9, More...
8 Night - St. Louis to Minneapolis
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 16, Jul 30, Sep 24, 2024: Jul 7, Jul 21, Aug 4, More...
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 16, Jul 30, Sep 24, 2024: Jul 7, Jul 21, Aug 4, More...
8 Night - St. Louis to Louisville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2023 Sails: Jul 31, More...
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2023 Sails: Jul 31, More...
8 Night - American Culinary Experience Cruise from St. Louis to Louisville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2023 Sails: Jul 31, More...
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2023 Sails: Jul 31, More...
7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2023 Sails: Aug 12, Aug 26, Sep 9, More...
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2023 Sails: Aug 12, Aug 26, Sep 9, More...
7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Sep 7, Sep 21, Oct 5, 2024: Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, More...
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Sep 7, Sep 21, Oct 5, 2024: Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, More...
7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Sep 30, More...
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2023 Sails: Sep 30, More...
14 Night - Grand Ohio River Cruise from St. Louis, MO to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Evansville, IN; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2024 Sails: Jun 29, More...
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Evansville, IN; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2024 Sails: Jun 29, More...