Ohio River Cruise Departures

River Cruises that depart from North America: United States: Ohio

River Cruises that visit Ohio

See all Cruises that depart from Ohio

Click on a cruise ship itinerary sailing from Ohio (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Cincinnati

American Queen Voyages, American Countess

8 Night - Cincinnati to Nashville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2023 Sails: May 8, More...

American Queen Voyages, American Countess

8 Night - Burbon: An American Spirit Cruise from Cincinnati to Nashville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Henderson, KY; Paducah, KY; Dover, TN; Clarksville, TN
2023 Sails: May 8, More...

American Queen Voyages, American Duchess

8 Night - Roundtrip Cincinnati
Starting in Cincinnati, OH; with stops in Louisville, KY; Madison, IN; Brandenburg, KY; Louisville, KY; Augusta, KY; Cincinnati, OH
2024 Sails: Apr 29, More...

American Queen Voyages, American Duchess

8 Night - Cincinnati to Pittsburgh
Starting in Cincinnati, OH; with stops in Augusta, KY; Maysville, KY; Huntington, WV; Point Pleasant, WV; Marietta, OH; Wheeling, WV; Pittsburgh, PA
2024 Sails: May 6, More...

Ohio River Cruise Departures